About Zinc finger SWIM domain-containing protein 5
Zinc finger SWIM domain-containing protein 5 (ZSWIM5) is a protein
from Homo sapiens identified by UniProt accession
Q9P217, 1185 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Zinc finger SWIM domain-containing protein 5 |
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| UniProt accession | Q9P217 |
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| Gene | ZSWIM5 |
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| Organism | Homo sapiens |
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| Length | 1185 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.18
- ringed hair disease · score 0.08
- Griscelli syndrome type 3 · score 0.08
- uncombable hair syndrome · score 0.08
- non-small cell lung carcinoma · score 0.07
- Griscelli disease type 3 · score 0.07
- Griscelli disease · score 0.07
- microcephaly-albinism-digital anomalies syndrome · score 0.06
- Microcephaly - albinism - digital anomalies · score 0.06
- lymphocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P217-F1 | alphafold | PREDICTED | 80.36 | — |
Amino-acid sequence (1185 residues)
MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS CLVLGARPHL QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW SFPRNEREIC MYSSFQYRGG PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF RRGIRLLDSG SVENVLQVGF HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK DIFYCAHVVA LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS QGGYCGSGKQ LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR QQGTNMTDKC RQLWDELGAL WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV CPLEDGNYGH ELPNITNALP QSAIHSPDSL SRPRRTVFTR AIEGRELHWQ DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP TACARVDALR SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS PNSSESYLSL ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ LDDELVQTLQ KQCILLLEGG PFSGLGEVIH RESVPMHTFA KYLFSALLPH DPDLSYKLAL RAMRLPVLEN SASAGDTSHP HHMVSVVPSR YPRWFTLGHL ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF KLAQDAFKIA TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA RTLALQCAMK DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL FTIARYMELR GYPLRAFKLA SLAMSHLNLA YNQDTHPAIN DVLWACALSH SLGKNELAAL IPLVVKSVHC ATVLSDILRR CTVTAPGLAG IPGRRSSGKL MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE FLSKARETFL LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG
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