About Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2) is a protein
from Homo sapiens identified by UniProt accession
Q9P242, 653 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 |
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| UniProt accession | Q9P242 |
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| Gene | NYAP2 |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.45
- self reported educational attainment · score 0.44
- wellbeing measurement · score 0.44
- smoking status measurement · score 0.43
- high density lipoprotein cholesterol measurement · score 0.40
- mathematical ability · score 0.40
- cortical surface area measurement · score 0.32
- smoking cessation · score 0.32
- depressive symptom measurement · score 0.32
- smoking initiation · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P242-F1 | alphafold | PREDICTED | 54.24 | — |
Amino-acid sequence (653 residues)
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR NETNLAYLKE KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP APQDRLPHPC SSGFSVRSQS LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK LSTSSETVSS TAASKSGKTP ERTEASAKPR PHSDEYSKKI PPPKPKRNPN TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE EEPVYIEMVG NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS DESPLTPLEV TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA LGPASATPAL SSSPPPPSTL YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV SQDGAKMVNA AVNTYGAAPG GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK STEELKVRSH STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA NRD
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