Probable tRNA methyltransferase 9B (TRMT9B)

About Probable tRNA methyltransferase 9B

Probable tRNA methyltransferase 9B (TRMT9B) is a protein from Homo sapiens identified by UniProt accession Q9P272, 454 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	Probable tRNA methyltransferase 9B
UniProt accession	Q9P272
Gene	TRMT9B
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

cortical thickness · score 0.35
hemoglobin measurement · score 0.31
protein measurement · score 0.27
metabolite measurement · score 0.16
self reported educational attainment · score 0.13
apolipoprotein A 1 measurement · score 0.11
balding measurement · score 0.10
early-onset non-syndromic cataract · score 0.10
neoplasm · score 0.10
emphysema imaging measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P272-F1	alphafold	PREDICTED	61.77	—

Amino-acid sequence (454 residues)

MDHEAAQLEK QHVHNVYEST APYFSDLQSK AWPRVRQFLQ EQKPGSLIAD IGCGTGKYLK VNSQVHTVGC DYCGPLVEIA RNRGCEAMVC DNLNLPFRDE GFDAIISIGV IHHFSTKQRR IRAIKEMARV LVPGGQLMIY VWAMEQKNRH FEKQDVLVPW NRALCSQLFS ESSQSGRKRQ CGYPERGHPY HPPCSECSCS VCFKEQCGSK RSHSVGYEPA MARTCFANIS KEGEEEYGFY STLGKSFRSW FFSRSLDEST LRKQIERVRP LKNTEVWASS TVTVQPSRHS SLDFDHQEPF STKGQSLDEE VFVESSSGKH LEWLRAPGTL KHLNGDHQGE MRRNGGGNFL DSTNTGVNCV DAGNIEDDNP SASKILRRIS AVDSTDFNPD DTMSVEDPQT DVLDSTAFMR YYHVFREGEL CSLLKENVSE LRILSSGNDH GNWCIIAEKK RGCD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards