BRCA2 and CDKN1A-interacting protein (BCCIP)

About BRCA2 and CDKN1A-interacting protein

BRCA2 and CDKN1A-interacting protein (BCCIP) is a protein from Homo sapiens identified by UniProt accession Q9P287, 314 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	BRCA2 and CDKN1A-interacting protein
UniProt accession	Q9P287
Gene	BCCIP
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
mean corpuscular hemoglobin concentration · score 0.33
erythrocyte count · score 0.27
mean corpuscular volume · score 0.25
lysosomal storage disease · score 0.25
mean corpuscular hemoglobin · score 0.17
appendicular lean mass · score 0.15
Red cell distribution width · score 0.11
red blood cell density measurement · score 0.10
blood protein measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P287-F1	alphafold	PREDICTED	79.41	—

Amino-acid sequence (314 residues)

MASRSKRRAV ESGVPQPPDP PVQRDEEEEK EVENEDEDDD DSDKEKDEED EVIDEEVNIE FEAYSLSDND YDGIKKLLQQ LFLKAPVNTA ELTDLLIQQN HIGSVIKQTD VSEDSNDDMD EDEVFGFISL LNLTERKGTQ CVEQIQELVL RFCEKNCEKS MVEQLDKFLN DTTKPVGLLL SERFINVPPQ IALPMYQQLQ KELAGAHRTN KPCGKCYFYL LISKTFVEAG KNNSKKKPSN KKKAALMFAN AEEEFFYEKA ILKFNYSVQE ESDTCLGGKW SFDDVPMTPL RTVMLIPGDK MNEIMDKLKE YLSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards