C5a anaphylatoxin chemotactic receptor 2 (C5AR2)

About C5a anaphylatoxin chemotactic receptor 2

C5a anaphylatoxin chemotactic receptor 2 (C5AR2) is a protein from Homo sapiens identified by UniProt accession Q9P296, 337 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	C5a anaphylatoxin chemotactic receptor 2
UniProt accession	Q9P296
Gene	C5AR2
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
ovarian cancer · score 0.25
glioblastoma multiforme · score 0.25
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.16
Blackfan-Diamond anemia · score 0.06
neoplasm · score 0.06
X-linked severe congenital neutropenia · score 0.05
myeloperoxidase deficiency · score 0.05
nonimmune chronic idiopathic neutropenia of adults · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P296-F1	alphafold	PREDICTED	86.48	—

Amino-acid sequence (337 residues)

MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV PGNAMVAWVA GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW PYGAVGCRAL PSIILLTMYA SVLLLAALSA DLCFLALGPA WWSTVQRACG VQVACGAAWT LALLLTVPSA IYRRLHQEHF PARLQCVVDY GGSSSTENAV TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV GFFVCWAPYH LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards