Transmembrane protein 181 (TMEM181)

About Transmembrane protein 181

Transmembrane protein 181 (TMEM181) is a protein from Homo sapiens identified by UniProt accession Q9P2C4, 475 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Transmembrane protein 181
UniProt accession	Q9P2C4
Gene	TMEM181
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

glaucoma · score 0.26
lipoprotein A measurement · score 0.26
open-angle glaucoma · score 0.26
intraocular pressure measurement · score 0.26
protein measurement · score 0.17
body height · score 0.14
heel bone mineral density · score 0.13
smoking status measurement · score 0.13
vital capacity · score 0.11
appendicular lean mass · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2C4-F1	alphafold	PREDICTED	78.08	—

Amino-acid sequence (475 residues)

MEPLAPMRLY TLSKRHFVLV FVVFFICFGL TIFVGIRGPK VIQTSAANFS LNNSKKLKPI QILSNPLSTY NQQLWLTCVV ELDQSKETSI KTSFPMTVKV DGVAQDGTTM YIHNKVHNRT RTLTCAGKCA EIIVAHLGYL NYTQYTVIVG FEHLKLPIKG MNFTWKTYNP AFSRLEIWFR FFFVVLTFIV TCLFAHSLRK FSMRDWGIEQ KWMSVLLPLL LLYNDPFFPL SFLVNSWLPG MLDDLFQSMF LCALLLFWLC VYHGIRVQGE RKCLTFYLPK FFIVGLLWLA SVTLGIWQTV NELHDPMYQY RVDTGNFQGM KVFFMVVAAV YILYLLFLIV RACSELRHMP YVDLRLKFLT ALTFVVLVIS IAILYLRFGA QVLQDNFVAE LSTHYQNSAE FLSFYGLLNF YLYTLAFVYS PSKNALYESQ LKDNPAFSML NDSDDDVIYG SDYEEMPLQN GQAIRAKYKE ESDSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards