About Dynein axonemal heavy chain 1
Dynein axonemal heavy chain 1 (DNAH1) is a protein
from Homo sapiens identified by UniProt accession
Q9P2D7, 4265 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Dynein axonemal heavy chain 1 |
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| UniProt accession | Q9P2D7 |
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| Gene | DNAH1 |
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| Organism | Homo sapiens |
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| Length | 4265 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (166)
Diseases linked to this target (Open Targets).
- spermatogenic failure 18 · score 0.78
- ciliary dyskinesia, primary, 37 · score 0.66
- primary ciliary dyskinesia · score 0.46
- non-syndromic male infertility due to sperm motility disorder · score 0.44
- neurodegenerative disease · score 0.25
- urate measurement · score 0.24
- triglyceride measurement · score 0.20
- high density lipoprotein cholesterol measurement · score 0.19
- chronotype measurement · score 0.15
- IGF-1 measurement · score 0.15
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (4265 residues)
MEQPNSKGYS LGRTPQGPEC SSAPAVQVGT HRGLEYNPGK ILPGSDYGLG NPPALDPKLP HLPLPPAPPT LSDLGQPRKS PLTGTDKKYP LMKQRGFYSD ILSPGTLDQL GEVCRGPRMS QNLLRQADLD KFTPRVGSFE VPEDFQERME QQCIGSTTRL LAQTDFPLQA YEPKMQVPFQ VLPGQHPRKI EIERRKQQYL SLDIEQLLFS QGIDSNKLMP RHLDHQHPQT IEQGHDPIFP IYLPLKVFDN EDFDCRTPRE WINMGLEPGS LDRKPVPGKA LLPTDDFLGH EDPKSQKLKY KWCEVGVLDY DEEKKLYLVH KTDEKGLVRD EMGRPILNAG VTTEGRPPLQ VCQYWVPRIQ LLFCAEDPCM FAQRVVQANA LRKNTEALLL YNLYVDCMPS DGQHVISEQS LSKIKQWALS TPRMRKGPSV LEHLSSLARE VSLDYERSMN KINFDHVVSS KPETFSYVTL PKKEEEQVPE RGLVSVPKYH FWEQKEDFTF VSLLTRPEVI TALSKVRAEC NKVTAMSLFH SSLSKYSHLE EFEQIQSQTF SQVQMFLKDS WISSLKVAMR SSLRDMSKGW YNLYETNWEV YLMSKLRKLM ELVKYMLQDT LRFLVQDSLA SFSQFISDTC CSVLNCTDDM VWGDDLINSP YRPRKNPLFI MDLVLDSSGV HYSTPLEQFE ASLLNLFDKG ILATHAVPQL EKLVMEDIFI SGDPLLESVG LHEPLVEELR ATIASAVSKA MIPLQAYAKE YRKYLELNNN DIASFLKTYQ TQGLLAQEVR EVVLTHLREK EILDSSLPSS IIIGPFYINT DNVKQSLSKK RKALATSVLD ILAKNLHKEV DSICEEFRSI SRKIYEKPNS IEELAELREW MKGIPERLVG LEERIVKVMD DYQVMDEFLY NLSSDDFNDK WIASNWPSKI LGQIELVQQQ HVEDEEKFRK IQIMDQNNFQ EKLEGLQLVV AGFSIHVEIS RAHEIANEVR RVKKQLKDCQ QLAMLYNNRE RIFSLPITNY DKLSRMVKEF QPYLDLWTTA SDWLRWSESW MNDPLSAIDA EQLEKNVVEA FKTMHKCVKQ FKDMPACQEV ALDIRARIEE FKPYIPLIQG LRNPGMRIRH WETLSNQINI NVRPKANLTF ARCLEMNLQD HIESISKVAE VAGKEYAIEQ ALDKMEKEWS TILFNVLPYK ATDTYILKSP DEASQLLDDH IVMTQNMSFS PYKKPFEQRI NSWENKLKLT QEVLEEWLNC QRSWLYLEPI FSSEDINQQL PVESKRYQTM ERIWKKIMKN AYENREVINV CSDLRMLDSL RDCNKILDLV QKGLSEYLET KRSAFPRFYF LSDDELLEIL SQTKDPTAVQ PHLRKCFENI ARLLFQEDLE ITHMYSAEGE EVQLCFSIYP SSNVEDWLRE VERSMKASVH DIIEKAIRAY PTMPRTQWVL NWPGQVTIAG CQTYWTMEVA EALEAGNLRS QLFPQLCQQL SDLVALVRGK LSRMQRAVLS ALIVIEVHAK DVVSKLIQEN VVSVNDFQWI SQLRYYWTNN DLYIRAVNAE FIYGYEYLGN SGRLVITPLT DRCYLTLTGA LHLKFGGAPA GPAGTGKTET TKDLGKALAI QTVVFNCSDQ LDFMAMGKFF KGLASAGAWA CFDEFNRIDI EVLSVVAQQI TTIQKAQQQR VERFMFEGVE IPLVPSCAVF ITMNPGYAGR TELPDNLKAL FRPVAMMVPD YAMITEISLY SFGFNEASVL AKKITTTFKL SSEQLSSQDH YDFGMRAVKT VISAAGNLKR ENPSMNEELI CLRAIRDVNV PKFLQEDLKL FSGIVSDLFP TIKEEDTDYG ILDEAIREAC RNSNLKDVEG FLTKCIQLYE TTVVRHGLML VGPTGSGKST CYRVLAAAMT SLKGQPSISG GMYEAVNYYV LNPKSITMGQ LYGEFDLLTH EWTDGIFSSF IRAGAITSDT NKKWYMFDGP VDAIWIENMN TVLDDNKKLC LSSGEIIKLT EAMTMMFEVQ DLAVASPATV SRCGMVYLEP SILGLMPFIE CWLRKLPPLL KPYEEHFKAL FVSFLEESIS FVRSSVKEVI ASTNCNLTMS LLKLLDCFFK PFLPREGLKK IPSEKLSRIV ELIEPWFIFS LIWSVGATGD SSGRTSFSHW LRLKMENEQL TLLFPEEGLV FDYRLEDAGI SGTNDSEDEE EEYKQVAWVK WMDSSAPFTM VPDTNYCNII VPTMDTVQMS HLLDMLLTNK KPVLCIGPTG TGKTLTISDK LLKNLALDYI SHFLTFSART SANQTQDFID SKLDKRRKGV FGPPLGRNFI FFIDDLNMPA LETYGAQPPI ELLRQWMDHG GWYDRKIIGA FKNLVDINFV CAMGPPGGGR NTVTPRLMRH FNYLSFAEMD EVSKKRIFST ILGNWLDGLL GEKSYRERVP GAPHIAHFTE PLVEATIMVY ATITSQLLPT PAKSHYTFNL RDLSKVFQGM LMADPAKVED QVQLLRLWYH ENCRVFRDRL VNEEDRSWFD QLLKRCMEQW EVTFNKVCPF QPILYGDFMS PGSDVKSYEL ITSESKMMQV IEEYIEDYNQ INTAKLKLVL FMDAMSHICR ISRTLRQALG NALLLGVGGS GRSSLTRLAS HMAEYECFQI ELSKNYGMSE WRDDVKKVLL KAGLQNLPIT FLFSDTQIKN ESFLEDINNV LNSGDIPNLY TADEQDQIVS TMRPYIQEQG LQPTKANLMA AYTGRVRSNI HMVLCMSPIG EVFRARLRQF PSLVNCCTID WFNEWPAEAL KSVATVFLNE IPELESSQEE IQGLIQVCVY IHQSVSKKCI EYLAELTRHN YVTPKSYLEL LHIFSILIGQ KKLELKTAKN RMKSGLDKLL RTSEDVAKMQ EDLESMHPLL EEAAKDTMLT MEQIKVDTAI AEETRNSVQT EEIKANEKAK KAQAIADDAQ KDLDEALPAL DAALASLRNL NKNDVTEVRA MQRPPPGVKL VIEAVCIMKG IKPKKVPGEK PGTKVDDYWE PGKGLLQDPG HFLESLFKFD KDNIGDVVIK AIQPYIDNEE FQPATIAKVS KACTSICQWV RAMHKYHFVA KAVEPKRQAL LEAQDDLGVT QRILDEAKQR LREVEDGIAT MQAKYRECIT KKEELELKCE QCEQRLGRAG KLINGLSDEK VRWQETVENL QYMLNNISGD VLVAAGFVAY LGPFTGQYRT VLYDSWVKQL RSHNVPHTSE PTLIGTLGNP VKIRSWQIAG LPNDTLSVEN GVINQFSQRW THFIDPQSQA NKWIKNMEKD NGLDVFKLSD RDFLRSMENA IRFGKPCLLE NVGEELDPAL EPVLLKQTYK QQGNTVLKLG DTVIPYHEDF RMYITTKLPN PHYTPEISTK LTLINFTLSP SGLEDQLLGQ VVAEERPDLE EAKNQLIISN AKMRQELKDI EDQILYRLSS SEGNPVDDME LIKVLEASKM KAAEIQAKVR IAEQTEKDID LTRMEYIPVA IRTQILFFCV SDLANVDPMY QYSLEWFLNI FLSGIANSER ADNLKKRISN INRYLTYSLY SNVCRSLFEK HKLMFAFLLC VRIMMNEGKI NQSEWRYLLS GGSISIMTEN PAPDWLSDRA WRDILALSNL PTFSSFSSDF VKHLSEFRVI FDSLEPHREP LPGIWDQYLD QFQKLLVLRC LRGDKVTNAM QDFVATNLEP RFIEPQTANL SVVFKDSNST TPLIFVLSPG TDPAADLYKF AEEMKFSKKL SAISLGQGQG PRAEAMMRSS IERGKWVFFQ NCHLAPSWMP ALERLIEHIN PDKVHRDFRL WLTSLPSNKF PVSILQNGSK MTIEPPRGVR ANLLKSYSSL GEDFLNSCHK VMEFKSLLLS LCLFHGNALE RRKFGPLGFN IPYEFTDGDL RICISQLKMF LDEYDDIPYK VLKYTAGEIN YGGRVTDDWD RRCIMNILED FYNPDVLSPE HSYSASGIYH QIPPTYDLHG YLSYIKSLPL NDMPEIFGLH DNANITFAQN ETFALLGTII QLQPKSSSAG SQGREEIVED VTQNILLKVP EPINLQWVMA KYPVLYEESM NTVLVQEVIR YNRLLQVITQ TLQDLLKALK GLVVMSSQLE LMAASLYNNT VPELWSAKAY PSLKPLSSWV MDLLQRLDFL QAWIQDGIPA VFWISGFFFP QAFLTGTLQN FARKFVISID TISFDFKVMF EAPSELTQRP QVGCYIHGLF LEGARWDPEA FQLAESQPKE LYTEMAVIWL LPTPNRKAQD QDFYLCPIYK TLTRAGTLST TGHSTNYVIA VEIPTHQPQR HWIKRGVALI CALDY
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