E3 ubiquitin-protein ligase MARCHF4 (MARCHF4)

About E3 ubiquitin-protein ligase MARCHF4

E3 ubiquitin-protein ligase MARCHF4 (MARCHF4) is a protein from Homo sapiens identified by UniProt accession Q9P2E8, 410 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase MARCHF4
UniProt accession	Q9P2E8
Gene	MARCHF4
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

protein measurement · score 0.24
sleep duration · score 0.23
high density lipoprotein cholesterol measurement · score 0.23
frontotemporal dementia · score 0.11
psoriasis · score 0.02
ependymoma · score 0.02
glioblastoma multiforme · score 0.02
astrocytoma · score 0.02
lung carcinoma · score 0.02
papillary thyroid carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2E8-F1	alphafold	PREDICTED	61.53	—

Amino-acid sequence (410 residues)

MLMPLCGLLW WWWCCCSGWY CYGLCAPAPQ MLRHQGLLKC RCRMLFNDLK VFLLRRPPQA PLPMHGDPQP PGLAANNTLP ALGAGGWAGW RGPREVVGRE PPPVPPPPPL PPSSVEDDWG GPATEPPASL LSSASSDDFC KEKTEDRYSL GSSLDSGMRT PLCRICFQGP EQGELLSPCR CDGSVKCTHQ PCLIKWISER GCWSCELCYY KYHVIAISTK NPLQWQAISL TVIEKVQVAA AILGSLFLIA SISWLIWSTF SPSARWQRQD LLFQICYGMY GFMDVVCIGL IIHEGPSVYR IFKRWQAVNQ QWKVLNYDKT KDLEDQKAGG RTNPRTSSST QANIPSSEEE TAGTPAPEQG PAQAAGHPSG PLSHHHCAYT ILHILSHLRP HEQRSPPGSS RELVMRVTTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards