About Kelch-like protein 14
Kelch-like protein 14 (KLHL14) is a protein
from Homo sapiens identified by UniProt accession
Q9P2G3, 628 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Kelch-like protein 14 |
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| UniProt accession | Q9P2G3 |
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| Gene | KLHL14 |
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| Organism | Homo sapiens |
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| Length | 628 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.33
- coronary artery disease · score 0.17
- adolescent idiopathic scoliosis · score 0.08
- Miyoshi myopathy · score 0.07
- TNF-related apoptosis-inducing ligand measurement · score 0.05
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
- protein measurement · score 0.04
- combined immunodeficiency with skin granulomas · score 0.04
- ovarian carcinoma · score 0.04
- clear cell renal carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2G3-F1 | alphafold | PREDICTED | 87.50 | — |
Amino-acid sequence (628 residues)
MSRSGDRTST FDPSHSDNLL HGLNLLWRKQ LFCDVTLTAQ GQQFHCHKAV LASCSQYFRS LFSSHPPLGG GVGGQDGLGA PKDQQQPPQQ QPSQQQQPPP QEEPGTPSSS PDDKLLTSPR AINNLVLQGC SSIGLRLVLE YLYTANVTLS LDTVEEVLSV SKILHIPQVT KLCVQFLNDQ ISVQNYKQVC KIAALHGLEE TKKLANKYLV EDVLLLNFEE MRALLDSLPP PVESELALFQ MSVLWLEHDR ETRMQYAPDL MKRLRFALIP APELVERVQS VDFMRTDPVC QKLLLDAMNY HLMPFRQHCR QSLASRIRSN KKMLLLVGGL PPGPDRLPSN LVQYYDDEKK TWKILTIMPY NSAHHCVVEV ENFLFVLGGE DQWNPNGKHS TNFVSRYDPR FNSWIQLPPM QERRASFYAC RLDKHLYVIG GRNETGYLSS VECYNLETNE WRYVSSLPQP LAAHAGAVHN GKIYISGGVH NGEYVPWLYC YDPVMDVWAR KQDMNTKRAI HTLAVMNDRL YAIGGNHLKG FSHLDVMLVE CYDPKGDQWN ILQTPILEGR SGPGCAVLDD SIYLVGGYSW SMGAYKSSTI CYCPEKGTWT ELEGDVAEPL AGPACVTVIL PSCVPYNK
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