About Kelch-like protein 8
Kelch-like protein 8 (KLHL8) is a protein
from Homo sapiens identified by UniProt accession
Q9P2G9, 620 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Kelch-like protein 8 |
|---|
| UniProt accession | Q9P2G9 |
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| Gene | KLHL8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 620 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.39
- hematocrit · score 0.37
- hemoglobin measurement · score 0.36
- cortical thickness · score 0.35
- sex hormone-binding globulin measurement · score 0.33
- mean platelet volume · score 0.32
- protein measurement · score 0.31
- total cholesterol measurement · score 0.29
- platelet count · score 0.27
- Red cell distribution width · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2G9-F1 | alphafold | PREDICTED | 90.66 | — |
Amino-acid sequence (620 residues)
MASDSMSSKQ ARNHITKGKR QQQHQQIKNR SSISDGDGED SFIFEANEAW KDFHGSLLRF YENGELCDVT LKVGSKLISC HKLVLACVIP YFRAMFLSEM AEAKQTLIEI RDFDGDAIED LVKFVYSSRL TLTVDNVQPL LYAACILQVE LVARACCEYM KLHFHPSNCL AVRAFAESHN RIDLMDMADQ YACDHFTEVV ECEDFVSVSP QHLHKLLSSS DLNIENEKQV YNAAIKWLLA NPQHHSKWLD ETLAQVRLPL LPVDFLMGVV AKEQIVKQNL KCRDLLDEAR NYHLHLSSRA VPDFEYSIRT TPRKHTAGVL FCVGGRGGSG DPFRSIECYS INKNSWFFGP EMNSRRRHVG VISVEGKVYA VGGHDGNEHL GSMEMFDPLT NKWMMKASMN TKRRGIALAS LGGPIYAIGG LDDNTCFNDV ERYDIESDQW STVAPMNTPR GGVGSVALVN HVYAVGGNDG MASLSSVERY DPHLDKWIEV KEMGQRRAGN GVSKLHGCLY VVGGFDDNSP LSSVERYDPR SNKWDYVAAL TTPRGGVGIA TVMGKIFAVG GHNGNAYLNT VEAFDPVLNR WELVGSVSHC RAGAGVAVCS CLTSQIRDVG HGSNNVVDCM
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