About Intraflagellar transport protein 80 homolog
Intraflagellar transport protein 80 homolog (IFT80) is a protein
from Homo sapiens identified by UniProt accession
Q9P2H3, 777 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 80 homolog |
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| UniProt accession | Q9P2H3 |
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| Gene | IFT80 |
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| Organism | Homo sapiens |
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| Length | 777 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (189)
Diseases linked to this target (Open Targets).
- Jeune syndrome · score 0.76
- Beemer-Langer syndrome · score 0.42
- neurodegenerative disease · score 0.42
- Short rib-polydactyly syndrome, Verma-Naumoff type · score 0.38
- Short rib-polydactyly syndrome, Beemer-Langer type · score 0.37
- short-rib thoracic dysplasia 6 with or without polydactyly · score 0.33
- platelet crit · score 0.28
- myeloproliferative disorder · score 0.28
- serum gamma-glutamyl transferase measurement · score 0.25
- serum alanine aminotransferase measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2H3-F1 | alphafold | PREDICTED | 92.33 | — |
Amino-acid sequence (777 residues)
MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETTQI VKLPDDIYPI DFHWFPKSLG VKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA LVTVGEDGQI KIWSKTGMLR STLAQQGTPV YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN DLILSAGEDC KYKVWDSYGR PLYNSQPHEH PITSVAWAPD GELFAVGSFH TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE QHWEWKNFQV TLTKRRAMQV RNVLNDAVDL LEFRDRVIKA SLNYAHLVVS TSLQCYVFST KNWNTPIIFD LKEGTVSLIL QAERHFLLVD GSSIYLYSYE GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IRDKADEKII FLFEASTGKP LGDGKFLSHK NEILEIALDQ KGLTNDRKIA FIDKNRDLCI TSVKRFGKEE QIIKLGTMVH TLAWNDTCNI LCGLQDTRFI VWYYPNTVYV DRDILPKTLY ERDASEFSKN PHIVSFVGNQ VTIRRADGSL VHISITPYPA ILHEYVSSSK WEDAVRLCRF VKEQTMWACL AAMAVANRDM TTAEIAYAAI GEIDKVQYIN SIKNLPSKES KMAHILLFSG NIQEAEIVLL QAGLVYQAIQ ININLYNWER ALELAVKYKT HVDTVLAYRQ KFLETFGKQE TNKRYLHYAE GLQIDWEKIK AKIEMEITKE REQSSSSQSS KSIGLKP
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