Protein turtle homolog A (IGSF9)

About Protein turtle homolog A

Protein turtle homolog A (IGSF9) is a protein from Homo sapiens identified by UniProt accession Q9P2J2, 1179 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Protein turtle homolog A
UniProt accession	Q9P2J2
Gene	IGSF9
Organism	Homo sapiens
Length	1179 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.18
cortical surface area measurement · score 0.17
brain measurement · score 0.16
cortical thickness · score 0.13
neuroimaging measurement · score 0.10
cancer · score 0.06
hypoparathyroidism, familial isolated, 2 · score 0.04
neoplasm · score 0.04
non-small cell lung carcinoma · score 0.04
pseudohypoparathyroidism type 2 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2J2-F1	alphafold	PREDICTED	66.20	—

Amino-acid sequence (1179 residues)

MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP PLHVIEWLRF GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV EDQGWYECRV FFLDQHIPED DFANGSWVHL TVNSPPQFQE TPPAVLEVQE LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG QGQVQVQNGT LRIRRVERGS SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA SQDVSLACHA EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP PLLFVSWTKD GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS LGTAGPSPVT RVLLKAPPAF IERPKEEYFQ EVGRELLIPC SAQGDPPPVV SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA HGHWECSASN AVARVATSTN VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS VWYTPLAKRP DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP KRLDGYVLEG RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA GSFVSDPSNT ANVSTSGLEV YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV LVSILAGCLL NRRRAARRRR KRLRQDPPLI FSPTGKSAAP SALGSGSPDS VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL PLEPICRGPD GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA APPDYMDTRR CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA DWTLRERLLP GLLPAAPRGS LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP APGDTSSWAS GPERWPRREH VVTVSKRRNT SVDENYEWDS EFPGDMELLE TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA RCAALREEFL AFRRRRDATR ARLPAYRQPV PHPEQATLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards