About Thioredoxin domain-containing protein 16
Thioredoxin domain-containing protein 16 (TXNDC16) is a protein
from Homo sapiens identified by UniProt accession
Q9P2K2, 825 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Thioredoxin domain-containing protein 16 |
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| UniProt accession | Q9P2K2 |
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| Gene | TXNDC16 |
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| Organism | Homo sapiens |
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| Length | 825 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.29
- heel bone mineral density · score 0.06
- prostate carcinoma · score 0.03
- chronic kidney disease · score 0.01
- glioblastoma multiforme · score 0.00
- Fabry disease · score 0.00
- meningococcal infection · score 0.00
- Alzheimer disease · score 0.00
- Pick disease · score 0.00
- endometriosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2K2-F1 | alphafold | PREDICTED | 80.80 | — |
Amino-acid sequence (825 residues)
MFSGFNVFRV GISFVIMCIF YMPTVNSLPE LSPQKYFSTL QPGKASLAYF CQADSPRTSV FLEELNEAVR PLQDYGISVA KVNCVKEEIS RYCGKEKDLM KAYLFKGNIL LREFPTDTLF DVNAIVAHVL FALLFSEVKY ITNLEDLQNI ENALKGKANI IFSYVRAIGI PEHRAVMEAA FVYGTTYQFV LTTEIALLES IGSEDVEYAH LYFFHCKLVL DLTQQCRRTL MEQPLTTLNI HLFIKTMKAP LLTEVAEDPQ QVSTVHLQLG LPLVFIVSQQ ATYEADRRTA EWVAWRLLGK AGVLLLLRDS LEVNIPQDAN VVFKRAEEGV PVEFLVLHDV DLIISHVENN MHIEEIQEDE DNDMEGPDID VQDDEVAETV FRDRKRKLPL ELTVELTEET FNATVMASDS IVLFYAGWQA VSMAFLQSYI DVAVKLKGTS TMLLTRINCA DWSDVCTKQN VTEFPIIKMY KKGENPVSYA GMLGTEDLLK FIQLNRISYP VNITSIQEAE EYLSGELYKD LILYSSVSVL GLFSPTMKTA KEDFSEAGNY LKGYVITGIY SEEDVLLLST KYAASLPALL LARHTEGKIE SIPLASTHAQ DIVQIITDAL LEMFPEITVE NLPSYFRLQK PLLILFSDGT VNPQYKKAIL TLVKQKYLDS FTPCWLNLKN TPVGRGILRA YFDPLPPLPL LVLVNLHSGG QVFAFPSDQA IIEENLVLWL KKLEAGLENH ITILPAQEWK PPLPAYDFLS MIDAATSQRG TRKVPKCMKE TDVQENDKEQ HEDKSAVRKE PIETLRIKHW NRSNWFKEAE KSFRRDKELG CSKVN
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