About REST corepressor 3
REST corepressor 3 (RCOR3) is a protein
from Homo sapiens identified by UniProt accession
Q9P2K3, 495 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | REST corepressor 3 |
|---|
| UniProt accession | Q9P2K3 |
|---|
| Gene | RCOR3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 495 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.26
- creatinine measurement · score 0.25
- mean reticulocyte volume · score 0.23
- mean corpuscular hemoglobin concentration · score 0.21
- platelet count · score 0.19
- neurodegenerative disease · score 0.18
- self reported educational attainment · score 0.17
- platelet crit · score 0.17
- blood urea nitrogen measurement · score 0.16
- cystatin C measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2K3-F1 | alphafold | PREDICTED | 68.36 | — |
Amino-acid sequence (495 residues)
MRVGAEYQAR IPEFDPGATK YTDKDNGGML VWSPYHSIPD AKLDEYIAIA KEKHGYNVEQ ALGMLFWHKH NIEKSLADLP NFTPFPDEWT VEDKVLFEQA FSFHGKSFHR IQQMLPDKTI ASLVKYYYSW KKTRSRTSLM DRQARKLANR HNQGDSDDDV EETHPMDGND SDYDPKKEAK KEGNTEQPVQ TSKIGLGRRE YQSLQHRHHS QRSKCRPPKG MYLTQEDVVA VSCSPNAANT ILRQLDMELI SLKRQVQNAK QVNSALKQKM EGGIEEFKPP ESNQKINARW TTEEQLLAVQ GVRKYGKDFQ AIADVIGNKT VGQVKNFFVN YRRRFNLEEV LQEWEAEQGT QASNGDASTL GEETKSASNV PSGKSTDEEE EAQTPQAPRT LGPSPPAPSS TPTPTAPIAT LNQPPPLLRP TLPAAPALHR QPPPLQQQAR FIQPRPTLNQ PPPPLIRPAN SMPPRLNPRP VLSTVGGQQP PSLIGIQTDS QSSLH
Explore REST corepressor 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets