About TBC1 domain family member 14
TBC1 domain family member 14 (TBC1D14) is a protein
from Homo sapiens identified by UniProt accession
Q9P2M4, 693 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | TBC1 domain family member 14 |
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| UniProt accession | Q9P2M4 |
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| Gene | TBC1D14 |
|---|
| Organism | Homo sapiens |
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| Length | 693 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.49
- leukocyte count · score 0.44
- myeloid white cell count · score 0.44
- monocyte percentage of leukocytes · score 0.44
- mean platelet volume · score 0.43
- mean corpuscular volume · score 0.42
- platelet count · score 0.40
- lymphocyte percentage of leukocytes · score 0.33
- monocyte count · score 0.33
- neutrophil percentage of leukocytes · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2M4-F1 | alphafold | PREDICTED | 65.39 | — |
Amino-acid sequence (693 residues)
MTDGKLSTST NGVAFMGILD GRPGNPLQNL QHVNLKAPRL LSAPEYGPKL KLRALEDRHS LQSVDSGIPT LEIGNPEPVP CSAVHVRRKQ SDSDLIPERA FQSACALPSC APPAPSSTER EQSVRKSSTF PRTGYDSVKL YSPTSKALTR SDDVSVCSVS SLGTELSTTL SVSNEDILDL VVTSSSSAIV TLENDDDPQF TNVTLSSIKE TRGLHQQDCV HEAEEGSKLK ILGPFSNFFA RNLLARKQSA RLDKHNDLGW KLFGKAPLRE NAQKDSKRIQ KEYEDKAGRP SKPPSPKQNV RKNLDFEPLS TTALILEDRP ANLPAKPAEE AQKHRQQYEE MVVQAKKREL KEAQRRKKQL EERCRVEESI GNAVLTWNNE ILPNWETMWC SRKVRDLWWQ GIPPSVRGKV WSLAIGNELN ITHELFDICL ARAKERWRSL STGGSEVENE DAGFSAADRE ASLELIKLDI SRTFPNLCIF QQGGPYHDML HSILGAYTCY RPDVGYVQGM SFIAAVLILN LDTADAFIAF SNLLNKPCQM AFFRVDHGLM LTYFAAFEVF FEENLPKLFA HFKKNNLTPD IYLIDWIFTL YSKSLPLDLA CRIWDVFCRD GEEFLFRTAL GILKLFEDIL TKMDFIHMAQ FLTRLPEDLP AEELFASIAT IQMQSRNKKW AQVLTALQKD SREMEKGSPS LRH
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