About Rho GTPase-activating protein 28
Rho GTPase-activating protein 28 (ARHGAP28) is a protein
from Homo sapiens identified by UniProt accession
Q9P2N2, 729 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Rho GTPase-activating protein 28 |
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| UniProt accession | Q9P2N2 |
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| Gene | ARHGAP28 |
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| Organism | Homo sapiens |
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| Length | 729 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.37
- asparaginase hypersensitivity · score 0.33
- sensorineural hearing loss · score 0.32
- erythrocyte count · score 0.31
- risk-taking behaviour · score 0.30
- macula measurement · score 0.29
- sudden cardiac arrest · score 0.05
- hippocampal sclerosis of aging · score 0.05
- osteosarcoma · score 0.04
- type 2 diabetes mellitus · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2N2-F1 | alphafold | PREDICTED | 72.89 | — |
Amino-acid sequence (729 residues)
MEVEDSGGVV LTAYHSYARA QPPNAESRCA PRAAASHPLS RKSIPRCRRI NRMLSNESLH PPAFSRSNSE ASVDSASMED FWREIESIKD SSMGGQEEPP PAEVTPVDEG ELEAEWLQDV GLSTLISGDE EEDGKALLST LTRTQAAAVQ KRYHTYTQTM RKKDKQSIRD VRDIFGVSES PPRDTCGNHT NQLDGTKEER ELPRVIKTSG SMPDDASLNS TTLSDASQDK EGSFAVPRSD SVAILETIPV LPVHSNGSPE PGQPVQNAIS DDDFLEKNIP PEAEELSFEV SYSEMVTEAL KRNKLKKSEI KKEDYVLTKF NVQKTRFGLT EAGDLSAEDM KKIRHLSLIE LTAFFDAFGI QLKRNKTEKV KGRDNGIFGV PLTVLLDGDR KKDPGVKVPL VLQKFFEKVE ESGLESEGIF RLSGCTAKVK QYREELDAKF NADKFKWDKM CHREAAVMLK AFFRELPTSL FPVEYIPAFI SLMERGPHVK VQFQALHLMV MALPDANRDA AQALMTFFNK VIANESKNRM SLWNISTVMA PNLFFSRSKH SDYEELLLAN TAAHIIRLML KYQKILWKVP SFLITQVRRM NEATMLLKKQ LPSVRKLLRR KTLERETASP KTSKVLQKSP SARRMSDVPE GVIRVHAPLL SKVSMAIQLN NQTKAKDILA KFQYENSHGS SECIKIQNQR LYEIGGNIGE HCLDPDAYIL DVYRINPQAE WVIKPQQSS
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