About Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) is a protein
from Homo sapiens identified by UniProt accession
Q9P2R7, 463 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial |
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| UniProt accession | Q9P2R7 |
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| Gene | SUCLA2 |
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| Organism | Homo sapiens |
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| Length | 463 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (102)
Diseases linked to this target (Open Targets).
- mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria · score 0.82
- mitochondrial DNA depletion syndrome · score 0.57
- neurodegenerative disease · score 0.49
- Leigh syndrome · score 0.37
- lysosomal storage disease · score 0.35
- mean corpuscular hemoglobin · score 0.35
- genetic disorder · score 0.34
- hip bone size · score 0.30
- mean corpuscular hemoglobin concentration · score 0.30
- red blood cell density measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2R7-F1 | alphafold | PREDICTED | 87.41 | — |
Amino-acid sequence (463 residues)
MAASMFYGRL VAVATLRNHR PRTAQRAAAQ VLGSSGLFNN HGLQVQQQQQ RNLSLHEYMS MELLQEAGVS VPKGYVAKSP DEAYAIAKKL GSKDVVIKAQ VLAGGRGKGT FESGLKGGVK IVFSPEEAKA VSSQMIGKKL FTKQTGEKGR ICNQVLVCER KYPRREYYFA ITMERSFQGP VLIGSSHGGV NIEDVAAESP EAIIKEPIDI EEGIKKEQAL QLAQKMGFPP NIVESAAENM VKLYSLFLKY DATMIEINPM VEDSDGAVLC MDAKINFDSN SAYRQKKIFD LQDWTQEDER DKDAAKANLN YIGLDGNIGC LVNGAGLAMA TMDIIKLHGG TPANFLDVGG GATVHQVTEA FKLITSDKKV LAILVNIFGG IMRCDVIAQG IVMAVKDLEI KIPVVVRLQG TRVDDAKALI ADSGLKILAC DDLDEAARMV VKLSEIVTLA KQAHVDVKFQ LPI
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