WD repeat-containing protein WRAP73 (WRAP73)

About WD repeat-containing protein WRAP73

WD repeat-containing protein WRAP73 (WRAP73) is a protein from Homo sapiens identified by UniProt accession Q9P2S5, 460 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	WD repeat-containing protein WRAP73
UniProt accession	Q9P2S5
Gene	WRAP73
Organism	Homo sapiens
Length	460 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
insomnia · score 0.05
total blood protein measurement · score 0.05
PHF-tau measurement · score 0.03
acute myeloid leukemia · score 0.03
neuroimaging measurement · score 0.02
cortical surface area measurement · score 0.02
diffuse large B-cell lymphoma · score 0.01
ulcerative colitis · score 0.00
breast cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2S5-F1	alphafold	PREDICTED	89.47	—

Amino-acid sequence (460 residues)

MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ IQHIEWSADS LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS LCTKSVSYIK YPKACLQGIT FTRDGRYMAL AERRDCKDYV SIFVCSDWQL LRHFDTDTQD LTGIEWAPNG CVLAVWDTCL EYKILLYSLD GRLLSTYSAY EWSLGIKSVA WSPSSQFLAV GSYDGKVRIL NHVTWKMITE FGHPAAINDP KIVVYKEAEK SPQLGLGCLS FPPPRAGAGP LPSSESKYEI ASVPVSLQTL KPVTDRANPK IGIGMLAFSP DSYFLATRND NIPNAVWVWD IQKLRLFAVL EQLSPVRAFQ WDPQQPRLAI CTGGSRLYLW SPAGCMSVQV PGEGDFAVLS LCWHLSGDSM ALLSKDHFCL CFLETEAVVG TACRQLGGHT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards