Sperm microtubule associated protein 2 (SPMAP2)

About Sperm microtubule associated protein 2

Sperm microtubule associated protein 2 (SPMAP2) is a protein from Homo sapiens identified by UniProt accession Q9P2T0, 379 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	Sperm microtubule associated protein 2
UniProt accession	Q9P2T0
Gene	SPMAP2
Organism	Homo sapiens
Length	379 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 65 · score 0.07
familial male-limited precocious puberty · score 0.07
spermatogenic failure 56 · score 0.07
spermatogenic failure 72 · score 0.07
spermatogenic failure, X-linked, 3 · score 0.07
spermatogenic failure 46 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2T0-F1	alphafold	PREDICTED	60.18	—

Amino-acid sequence (379 residues)

MGDSRRRSLG NQPSSEAAGR SEREQDGDPR GLQSSVYESR RVTDPERQDL DNAELGPEDP EEELPPEEVA GEEFPETLDP KEALSELERV LDKDLEEDIP EISRLSISQK LPSTTMTKAR KRRRRRRLME LAEPKINWQV LKDRKGRCGK GYAWISPCKM SLHFCLCWPS VYWTERFLED TTLTITVPAV SRRVEELSRP KRFYLEYYNN NRTTPVWPIP RSSLEYRASS RLKELAAPKI RDNFWSMPMS EVSQVSRAAQ MAVPSSRILQ LSKPKAPATL LEEWDPVPKP KPHVSDHNRL LHLARPKAQS DKCVPDRDPR WEVLDVTKKV VASPRIISLA KPKVRKGLNE GYDRRPLASM SLPPPKASPE KCDQPRPGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards