GMP reductase 2 (GMPR2)

About GMP reductase 2

GMP reductase 2 (GMPR2) is a protein from Homo sapiens identified by UniProt accession Q9P2T1, 348 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	GMP reductase 2
UniProt accession	Q9P2T1
Gene	GMPR2
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin · score 0.20
mean corpuscular volume · score 0.20
mean corpuscular hemoglobin concentration · score 0.19
Abnormality of refraction · score 0.15
platelet count · score 0.12
erythrocyte count · score 0.10
telomere length · score 0.08
uterine fibroid · score 0.08
red blood cell density measurement · score 0.05
myeloid white cell count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2T1-F1	alphafold	PREDICTED	96.80	—

Amino-acid sequence (348 residues)

MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards