About Vesicular glutamate transporter 1
Vesicular glutamate transporter 1 (SLC17A7) is a protein
from Homo sapiens identified by UniProt accession
Q9P2U7, 560 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | Vesicular glutamate transporter 1 |
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| UniProt accession | Q9P2U7 |
|---|
| Gene | SLC17A7 |
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| Organism | Homo sapiens |
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| Length | 560 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (131)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.13
- squamous cell lung carcinoma · score 0.11
- fragile X syndrome · score 0.06
- fetal growth restriction · score 0.06
- glioblastoma multiforme · score 0.05
- Tinnitus · score 0.05
- Spinal cord injury · score 0.04
- central nervous system cancer · score 0.04
- atypical teratoid rhabdoid tumor · score 0.04
- mean corpuscular volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2U7-F1 | alphafold | PREDICTED | 80.03 | — |
Amino-acid sequence (560 residues)
MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG HVVVQKAQFS WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPLTK FSTPWRRFFT SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP EEMSEEKCGF VGHDQLAGSD DSEMEDEAEP PGAPPAPPPS YGATHSTFQP PRPPPPVRDY
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