About Vesicular glutamate transporter 2
Vesicular glutamate transporter 2 (SLC17A6) is a protein
from Homo sapiens identified by UniProt accession
Q9P2U8, 582 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Vesicular glutamate transporter 2 |
|---|
| UniProt accession | Q9P2U8 |
|---|
| Gene | SLC17A6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 582 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (133)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.36
- hypertension · score 0.31
- PHF-tau measurement · score 0.25
- protein measurement · score 0.21
- mean arterial pressure · score 0.18
- diastolic blood pressure · score 0.18
- Beta blocking agent use measurement · score 0.16
- platelet count · score 0.15
- aspartate aminotransferase measurement · score 0.14
- serum alanine aminotransferase measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2U8-F1 | alphafold | PREDICTED | 78.24 | — |
Amino-acid sequence (582 residues)
MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS
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