About Homologous-pairing protein 2 homolog
Homologous-pairing protein 2 homolog (PSMC3IP) is a protein
from Homo sapiens identified by UniProt accession
Q9P2W1, 217 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Homologous-pairing protein 2 homolog |
|---|
| UniProt accession | Q9P2W1 |
|---|
| Gene | PSMC3IP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 217 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (166)
Diseases linked to this target (Open Targets).
- 46,XX gonadal dysgenesis · score 0.58
- neurodegenerative disease · score 0.27
- primary ovarian insufficiency · score 0.20
- Premature ovarian insufficiency · score 0.18
- premature menopause · score 0.18
- lung adenocarcinoma · score 0.18
- monocyte count · score 0.11
- blood pressure · score 0.10
- type 2 diabetes mellitus · score 0.10
- serum gamma-glutamyl transferase measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2W1-F1 | alphafold | PREDICTED | 92.11 | — |
Amino-acid sequence (217 residues)
MSKGRAEAAA GAAGILLRYL QEQNRPYSSQ DVFGNLQREH GLGKAVVVKT LEQLAQQGKI KEKMYGKQKI YFADQDQFDM VSDADLQVLD GKIVALTAKV QSLQQSCRYM EAELKELSSA LTTPEMQKEI QELKKECAGY RERLKNIKAA TNHVTPEEKE QVYRERQKYC KEWRKRKRMA TELSDAILEG YPKSKKQFFE EVGIETDEDY NVTLPDP
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