Syntaxin-18 (STX18)

About Syntaxin-18

Syntaxin-18 (STX18) is a protein from Homo sapiens identified by UniProt accession Q9P2W9, 335 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Syntaxin-18
UniProt accession	Q9P2W9
Gene	STX18
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
diabetic maculopathy · score 0.34
adolescent idiopathic scoliosis · score 0.23
lower face morphology measurement · score 0.23
3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.22
congenital heart disease · score 0.16
MODY · score 0.07
3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.05
hyperproinsulinemia · score 0.05
exercise-induced hyperinsulinism · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2W9-F1	alphafold	PREDICTED	72.17	—

Amino-acid sequence (335 residues)

MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards