About Dolichol-phosphate mannosyltransferase subunit 3
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) is a protein
from Homo sapiens identified by UniProt accession
Q9P2X0, 92 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Dolichol-phosphate mannosyltransferase subunit 3 |
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| UniProt accession | Q9P2X0 |
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| Gene | DPM3 |
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| Organism | Homo sapiens |
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| Length | 92 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (85)
Diseases linked to this target (Open Targets).
- DPM3-congenital disorder of glycosylation · score 0.80
- muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 15 · score 0.63
- congenital disorder of glycosylation · score 0.54
- congenital disorder of glycosylation type I · score 0.50
- neurodegenerative disease · score 0.37
- cardiomyopathy · score 0.27
- myopathy · score 0.27
- EMG: myopathic abnormalities · score 0.27
- hematocrit · score 0.12
- serum gamma-glutamyl transferase measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2X0-F1 | alphafold | PREDICTED | 88.86 | — |
Amino-acid sequence (92 residues)
MTKLAQWLWG LAILGSTWVA LTTGALGLEL PLSCQEVLWP LPAYLLVSAG CYALGTVGYR VATFHDCEDA ARELQSQIQE ARADLARRGL RF
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