About UV radiation resistance-associated gene protein
UV radiation resistance-associated gene protein (UVRAG) is a protein
from Homo sapiens identified by UniProt accession
Q9P2Y5, 699 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | UV radiation resistance-associated gene protein |
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| UniProt accession | Q9P2Y5 |
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| Gene | UVRAG |
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| Organism | Homo sapiens |
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| Length | 699 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (181)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- COVID-19 · score 0.46
- lysosomal storage disease · score 0.37
- severe acute respiratory syndrome · score 0.37
- high density lipoprotein cholesterol measurement · score 0.33
- bilirubin measurement · score 0.32
- mean corpuscular volume · score 0.30
- apolipoprotein A 1 measurement · score 0.28
- phosphatidylcholine measurement · score 0.27
- total cholesterol measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2Y5-F1 | alphafold | PREDICTED | 67.63 | — |
Amino-acid sequence (699 residues)
MSASASVGGP VPQPPPGPAA ALPPGSAARA LHVELPSQQR RLRHLRNIAA RNIVNRNGHQ LLDTYFTLHL CSTEKIYKEF YRSEVIKNSL NPTWRSLDFG IMPDRLDTSV SCFVVKIWGG KENIYQLLIE WKVCLDGLKY LGQQIHARNQ NEIIFGLNDG YYGAPFEHKG YSNAQKTILL QVDQNCVRNS YDVFSLLRLH RAQCAIKQTQ VTVQKIGKEI EEKLRLTSTS NELKKKSECL QLKILVLQNE LERQKKALGR EVALLHKQQI ALQDKGSAFS AEHLKLQLQK ESLNELRKEC TAKRELFLKT NAQLTIRCRQ LLSELSYIYP IDLNEHKDYF VCGVKLPNSE DFQAKDDGSI AVALGYTAHL VSMISFFLQV PLRYPIIHKG SRSTIKDNIN DKLTEKEREF PLYPKGGEKL QFDYGVYLLN KNIAQLRYQH GLGTPDLRQT LPNLKNFMEH GLMVRCDRHH TSSAIPVPKR QSSIFGGADV GFSGGIPSPD KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET ERKITSLSSS LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE AFNCIPVDSA VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK
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