About THAP domain-containing protein 10
THAP domain-containing protein 10 (THAP10) is a protein
from Homo sapiens identified by UniProt accession
Q9P2Z0, 257 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | THAP domain-containing protein 10 |
|---|
| UniProt accession | Q9P2Z0 |
|---|
| Gene | THAP10 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 257 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.18
- brain volume measurement · score 0.17
- protein measurement · score 0.15
- appendicular lean mass · score 0.13
- FEV/FVC ratio · score 0.08
- acute myeloid leukemia · score 0.07
- macula measurement · score 0.05
- eosinophil count · score 0.04
- brain measurement · score 0.04
- metabolite measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2Z0-F1 | alphafold | PREDICTED | 62.92 | — |
Amino-acid sequence (257 residues)
MPARCVAAHC GNTTKSGKSL FRFPKDRAVR LLWDRFVRGC RADWYGGNDR SVICSDHFAP ACFDVSSVIQ KNLRFSQRLR LVAGAVPTLH RVPAPAPKRG EEGDQAGRLD TRGELQAARH SEAAPGPVSC TRPRAGKQAA ASQITCENEL VQTQPHADNP SNTVTSVPTH CEEGPVHKST QISLKRPRHR SVGIQAKVKA FGKRLCNATT QTEELWSRTS SLFDIYSSDS ETDTDWDIKS EQSDLSYMAV QVKEETC
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