Hepatocyte nuclear factor 6 (ONECUT1)

About Hepatocyte nuclear factor 6

Hepatocyte nuclear factor 6 (ONECUT1) is a protein from Homo sapiens identified by UniProt accession Q9UBC0, 465 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.

Target properties

Protein name	Hepatocyte nuclear factor 6
UniProt accession	Q9UBC0
Gene	ONECUT1
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (173)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
sex hormone-binding globulin measurement · score 0.52
C-reactive protein measurement · score 0.43
body mass index · score 0.42
alkaline phosphatase measurement · score 0.39
testosterone measurement · score 0.39
type 2 diabetes mellitus · score 0.38
mean corpuscular hemoglobin concentration · score 0.38
body fat percentage · score 0.37
neonatal diabetes mellitus · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBC0-F1	alphafold	PREDICTED	59.40	—

Amino-acid sequence (465 residues)

MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP RSMGMASLLD GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSSSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGSS NSGNSSSSSS TCTKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards