NF-kappa-B inhibitor-like protein 1 (NFKBIL1)

About NF-kappa-B inhibitor-like protein 1

NF-kappa-B inhibitor-like protein 1 (NFKBIL1) is a protein from Homo sapiens identified by UniProt accession Q9UBC1, 381 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	NF-kappa-B inhibitor-like protein 1
UniProt accession	Q9UBC1
Gene	NFKBIL1
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.42
age at menopause · score 0.17
childhood onset asthma · score 0.14
mortality · score 0.08
Sepsis · score 0.08
natural cytotoxicity triggering receptor 3 measurement · score 0.07
MHC class I polypeptide-related sequence B measurement · score 0.06
Takayasu arteritis · score 0.06
urate measurement · score 0.05
allergic disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBC1-F1	alphafold	PREDICTED	77.16	—

Amino-acid sequence (381 residues)

MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ ALLQRHPGLD VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT ALHAAARQGP DAYTDFFLPL LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS AEEEEEDDAS KEREWRQKLQ GELEDEWQEV MGRFEGDASH ETQEPESFSA WSDRLAREHA QKCQQQQREA EGSRRPPRAE GSSQSWRQQE EEQRLFRERA RAKEEELRES RARRAQEALG DREPKPTRAG PREEHPRGAG RGSLWRFGDV PWPCPGGGDP EAMAAALVAR GPPLEEQGAL RRYLRVQQVR WHPDRFLQRF RSQIETWELG RVMGAVTALS QALNRHAEAL K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards