About Small proline-rich protein 3
Small proline-rich protein 3 (SPRR3) is a protein
from Homo sapiens identified by UniProt accession
Q9UBC9, 169 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Small proline-rich protein 3 |
|---|
| UniProt accession | Q9UBC9 |
|---|
| Gene | SPRR3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 169 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- prostate adenocarcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.20
- ovarian cancer · score 0.18
- non-small cell lung carcinoma · score 0.09
- oral squamous cell carcinoma · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- psoriasis · score 0.07
- glioblastoma multiforme · score 0.07
- pentosuria · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBC9-F1 | alphafold | PREDICTED | 52.69 | — |
Amino-acid sequence (169 residues)
MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK
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