About Myotilin
Myotilin (MYOT) is a protein
from Homo sapiens identified by UniProt accession
Q9UBF9, 498 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Myotilin |
|---|
| UniProt accession | Q9UBF9 |
|---|
| Gene | MYOT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 498 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- myofibrillar myopathy 3 · score 0.78
- Distal myotilinopathy · score 0.66
- limb-girdle muscular dystrophy · score 0.55
- Distal lower limb muscle weakness · score 0.34
- EMG: myopathic abnormalities · score 0.34
- Lower limb pain · score 0.34
- Foot dorsiflexor weakness · score 0.34
- myofibrillar myopathy · score 0.33
- Progressive distal muscle weakness · score 0.27
- red blood cell density measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBF9-F1 | alphafold | PREDICTED | 64.80 | — |
Amino-acid sequence (498 residues)
MFNYERPKHF IQSQNPCGSR LQPPGPETSS FSSQTKQSSI IIQPRQCTEQ RFSASSTLSS HITMSSSAFP ASPKQHAGSN PGQRVTTTYN QSPASFLSSI LPSQPDYNSS KIPSAMDSNY QQSSAGQPIN AKPSQTANAK PIPRTPDHEI QGSKEALIQD LERKLKCKDT LLHNGNQRLT YEEKMARRLL GPQNAAAVFQ AQDDSGAQDS QQHNSEHARL QVPTSQVRSR STSRGDVNDQ DAIQEKFYPP RFIQVPENMS IDEGRFCRMD FKVSGLPAPD VSWYLNGRTV QSDDLHKMIV SEKGLHSLIF EVVRASDAGA YACVAKNRAG EATFTVQLDV LAKEHKRAPM FIYKPQSKKV LEGDSVKLEC QISAIPPPKL FWKRNNEMVQ FNTDRISLYQ DNTGRVTLLI KDVNKKDAGW YTVSAVNEAG VTTCNTRLDV TARPNQTLPA PKQLRVRPTF SKYLALNGKG LNVKQAFNPE GEFQRLAAQS GLYESEEL
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