Cornulin (CRNN)

About Cornulin

Cornulin (CRNN) is a protein from Homo sapiens identified by UniProt accession Q9UBG3, 495 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Cornulin
UniProt accession	Q9UBG3
Gene	CRNN
Organism	Homo sapiens
Length	495 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

esophageal squamous cell carcinoma · score 0.40
esophageal cancer · score 0.37
atopic eczema · score 0.20
atopic march · score 0.11
childhood onset asthma · score 0.11
oral squamous cell carcinoma · score 0.06
Eczematoid dermatitis · score 0.05
dermatitis · score 0.05
neoplasm · score 0.05
colorectal adenocarcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBG3-F1	alphafold	PREDICTED	48.88	—

Amino-acid sequence (495 residues)

MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST ESGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards