About Recombining binding protein suppressor of hairless-like protein
Recombining binding protein suppressor of hairless-like protein (RBPJL) is a protein
from Homo sapiens identified by UniProt accession
Q9UBG7, 517 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Recombining binding protein suppressor of hairless-like protein |
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| UniProt accession | Q9UBG7 |
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| Gene | RBPJL |
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| Organism | Homo sapiens |
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| Length | 517 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.20
- bipolar I disorder · score 0.11
- bipolar disorder · score 0.11
- alkaline phosphatase measurement · score 0.07
- blood protein measurement · score 0.07
- Asperger syndrome · score 0.05
- neoplasm · score 0.05
- autism · score 0.04
- intellectual disability, autosomal recessive 58 · score 0.03
- intellectual disability, autosomal dominant 50 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBG7-F1 | alphafold | PREDICTED | 80.17 | — |
Amino-acid sequence (517 residues)
MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT TILRGGVRRC LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG WRVKPGQDQA HQAGETGPTV CGYMGLDSAS GSATETQKLN FEQQPDSREF GCAKTLYISD ADKRKHFRLV LRLVLRGGRE LGTFHSRLIK VISKPSQKKQ SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA SARQWAAFTL HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR ALLNDSSCWT IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA TLELHGENFH AGLKVWFGDV EAETMYRSPR SLVCVVPDVA AFCSDWRWLR APITIPMSLV RADGLFYPSA FSFTYTPEYS VRPGHPGVPE PATDADALLE SIHQEFTRTN FHLFIQT
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