About Interleukin-36 receptor antagonist protein
Interleukin-36 receptor antagonist protein (IL36RN) is a protein
from Homo sapiens identified by UniProt accession
Q9UBH0, 155 residues long.
MolForge cross-references it against 0 known binders and
222 disease associations.
Target properties
| Protein name | Interleukin-36 receptor antagonist protein |
|---|
| UniProt accession | Q9UBH0 |
|---|
| Gene | IL36RN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 155 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (222)
Diseases linked to this target (Open Targets).
- psoriasis 14, pustular · score 0.81
- autoinflammatory syndrome · score 0.45
- pustulosis palmaris et plantaris · score 0.38
- interleukin 1 receptor antagonist measurement · score 0.32
- genetic disorder · score 0.17
- quality of life during menstruation measurement · score 0.14
- drug use measurement · score 0.14
- PHF-tau measurement · score 0.12
- neutrophil count · score 0.09
- Chronic mucocutaneous candidosis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBH0-F1 | alphafold | PREDICTED | 92.45 | — |
Amino-acid sequence (155 residues)
MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD
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