About Solute carrier family 53 member 1
Solute carrier family 53 member 1 (XPR1) is a protein
from Homo sapiens identified by UniProt accession
Q9UBH6, 696 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Solute carrier family 53 member 1 |
|---|
| UniProt accession | Q9UBH6 |
|---|
| Gene | XPR1 |
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| Organism | Homo sapiens |
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| Length | 696 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- basal ganglia calcification, idiopathic, 6 · score 0.76
- bilateral striopallidodentate calcinosis · score 0.38
- protein measurement · score 0.27
- systolic blood pressure · score 0.23
- ovarian carcinoma · score 0.22
- carcinoma of gallbladder and extrahepatic biliary tract · score 0.22
- genetic disorder · score 0.19
- Seizure · score 0.12
- drug use measurement · score 0.09
- body height · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBH6-F1 | alphafold | PREDICTED | 83.96 | — |
Amino-acid sequence (696 residues)
MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY FAKFEEKFFQ TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE STGVTTLRQR RKPVFHLSHE ERVQHRNIKD LKLAFSEFYL SLILLQNYQN LNFTGFRKIL KKHDKILETS RGADWRVAHV EVAPFYTCKK INQLISETEA VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF CGIFIVLNIT LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA LYGFMVFFLI NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL NSLSVILMDL EYMICFYSLE LKWDESKGLL PNNSEESGIC HKYTYGVRAI VQCIPAWLRF IQCLRRYRDT KRAFPHLVNA GKYSTTFFMV TFAALYSTHK ERGHSDTMVF FYLWIVFYII SSCYTLIWDL KMDWGLFDKN AGENTFLREE IVYPQKAYYY CAIIEDVILR FAWTIQISIT STTLLPHSGD IIATVFAPLE VFRRFVWNFF RLENEHLNNC GEFRAVRDIS VAPLNADDQT LLEQMMDQDD GVRNRQKNRS WKYNQSISLR RPRLASQSKA RDTKVLIEDT DDEANT
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