About ATP-binding cassette sub-family D member 2
ATP-binding cassette sub-family D member 2 (ABCD2) is a protein
from Homo sapiens identified by UniProt accession
Q9UBJ2, 740 residues long.
MolForge cross-references it against 0 known binders and
153 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family D member 2 |
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| UniProt accession | Q9UBJ2 |
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| Gene | ABCD2 |
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| Organism | Homo sapiens |
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| Length | 740 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (153)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.13
- infection · score 0.10
- infect · score 0.10
- leukocyte count · score 0.06
- X-linked adrenoleukodystrophy · score 0.06
- spinocerebellar ataxia type 17 · score 0.05
- neurodegeneration with brain iron accumulation 2A · score 0.05
- spinocerebellar ataxia type 35 · score 0.05
- Young adult-onset Parkinsonism · score 0.05
- behavioral variant of frontotemporal dementia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBJ2-F1 | alphafold | PREDICTED | 81.00 | — |
Amino-acid sequence (740 residues)
MTHMLNAAAD RVKWTRSSAA KRAACLVAAA YALKTLYPII GKRLKQSGHG KKKAAAYPAA ENTEILHCTE TICEKPSPGV NADFFKQLLE LRKILFPKLV TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW LMIAIPATFV NSAIRYLECK LALAFRTRLV DHAYETYFTN QTYYKVINMD GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVMLTSY TLIQTATSRG ASPIGPTLLA GLVVYATAKV LKACSPKFGK LVAEEAHRKG YLRYVHSRII ANVEEIAFYR GHKVEMKQLQ KSYKALADQM NLILSKRLWY IMIEQFLMKY VWSSSGLIMV AIPIITATGF ADGEDGQKQV MVSERTEAFT TARNLLASGA DAIERIMSSY KEVTELAGYT ARVYNMFWVF DEVKRGIYKR TAVIQESESH SKNGAKVELP LSDTLAIKGK VIDVDHGIIC ENVPIITPAG EVVASRLNFK VEEGMHLLIT GPNGCGKSSL FRILSGLWPV YEGVLYKPPP QHMFYIPQRP YMSLGSLRDQ VIYPDSVDDM HDKGYTDQDL ERILHNVHLY HIVQREGGWD AVMDWKDVLS GGEKQRMGMA RMFYHKPKYA LLDECTSAVS IDVEGKIFQA AKGAGISLLS ITHRPSLWKY HTHLLQFDGE GGWRFEQLDT AIRLTLSEEK QKLESQLAGI PKMQQRLNEL CKILGEDSVL KTIKNEDETS
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