About Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a protein
from Homo sapiens identified by UniProt accession
Q9UBK2, 798 residues long.
MolForge cross-references it against 0 known binders and
811 disease associations.
Target properties
| Protein name | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha |
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| UniProt accession | Q9UBK2 |
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| Gene | PPARGC1A |
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| Organism | Homo sapiens |
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| Length | 798 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (811)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.51
- hematocrit · score 0.50
- electrocardiography · score 0.49
- sex hormone-binding globulin measurement · score 0.49
- erythrocyte count · score 0.47
- creatinine measurement · score 0.45
- glomerular filtration rate · score 0.44
- mean corpuscular hemoglobin concentration · score 0.44
- red blood cell density measurement · score 0.44
- self reported educational attainment · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBK2-F1 | alphafold | PREDICTED | 52.74 | — |
Amino-acid sequence (798 residues)
MAWDMCNQDS ESVWSDIECA ALVGEDQPLC PDLPELDLSE LDVNDLDTDS FLGGLKWCSD QSEIISNQYN NEPSNIFEKI DEENEANLLA VLTETLDSLP VDEDGLPSFD ALTDGDVTTD NEASPSSMPD GTPPPQEAEE PSLLKKLLLA PANTQLSYNE CSGLSTQNHA NHNHRIRTNP AIVKTENSWS NKAKSICQQQ KPQRRPCSEL LKYLTTNDDP PHTKPTENRN SSRDKCTSKK KSHTQSQSQH LQAKPTTLSL PLTPESPNDP KGSPFENKTI ERTLSVELSG TAGLTPPTTP PHKANQDNPF RASPKLKSSC KTVVPPPSKK PRYSESSGTQ GNNSTKKGPE QSELYAQLSK SSVLTGGHEE RKTKRPSLRL FGDHDYCQSI NSKTEILINI SQELQDSRQL ENKDVSSDWQ GQICSSTDSD QCYLRETLEA SKQVSPCSTR KQLQDQEIRA ELNKHFGHPS QAVFDDEADK TGELRDSDFS NEQFSKLPMF INSGLAMDGL FDDSEDESDK LSYPWDGTQS YSLFNVSPSC SSFNSPCRDS VSPPKSLFSQ RPQRMRSRSR SFSRHRSCSR SPYSRSRSRS PGSRSSSRSC YYYESSHYRH RTHRNSPLYV RSRSRSPYSR RPRYDSYEEY QHERLKREEY RREYEKRESE RAKQRERQRQ KAIEERRVIY VGKIRPDTTR TELRDRFEVF GEIEECTVNL RDDGDSYGFI TYRYTCDAFA ALENGYTLRR SNETDFELYF CGRKQFFKSN YADLDSNSDD FDPASTKSKY DSLDFDSLLK EAQRSLRR
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