Hematopoietic cell signal transducer (HCST)

About Hematopoietic cell signal transducer

Hematopoietic cell signal transducer (HCST) is a protein from Homo sapiens identified by UniProt accession Q9UBK5, 93 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Hematopoietic cell signal transducer
UniProt accession	Q9UBK5
Gene	HCST
Organism	Homo sapiens
Length	93 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

pancreatic adenocarcinoma · score 0.18
neoplasm · score 0.09
melorheostosis · score 0.07
Gorham-Stout disease · score 0.07
12q14 microdeletion syndrome · score 0.07
dacryocystitis-osteopoikilosis syndrome · score 0.06
pyknoachondrogenesis · score 0.06
autosomal recessive osteopetrosis 6 · score 0.06
Intermediate osteopetrosis · score 0.06
osteomesopyknosis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBK5-F1	alphafold	PREDICTED	67.15	—

Amino-acid sequence (93 residues)

MIHLGHILFL LLLPVAAAQT TPGERSSLPA FYPGTSGSCS GCGSLSLPLL AGLVAADAVA SLLIVGAVFL CARPRRSPAQ EDGKVYINMP GRG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards