About cAMP-regulated phosphoprotein 21
cAMP-regulated phosphoprotein 21 (ARPP21) is a protein
from Homo sapiens identified by UniProt accession
Q9UBL0, 812 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | cAMP-regulated phosphoprotein 21 |
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| UniProt accession | Q9UBL0 |
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| Gene | ARPP21 |
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| Organism | Homo sapiens |
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| Length | 812 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (99)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.46
- body mass index · score 0.45
- body fat percentage · score 0.42
- age at first sexual intercourse measurement · score 0.42
- worry measurement · score 0.42
- BMI-adjusted waist-hip ratio · score 0.40
- waist-hip ratio · score 0.39
- fat body mass · score 0.38
- lean body mass · score 0.38
- intelligence · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBL0-F1 | alphafold | PREDICTED | 51.52 | — |
Amino-acid sequence (812 residues)
MSEQGDLNQA IAEEGGTEQE TATPENGIVK SESLDEEEKL ELQRRLEAQN QERRKSKSGA GKGKLTRSLA VCEESSARPG GESLQDQESI HLQLSSFSSL QEEDKSRKDD SEREKEKDKN KDKTSEKPKI RMLSKDCSQE YTDSTGIDLH EFLINTLKNN SRDRMILLKM EQEIIDFIAD NNNHYKKFPQ MSSYQRMLVH RVAAYFGLDH NVDQTGKSVI INKTSSTRIP EQRFCEHLKD EKGEESQKRF ILKRDNSSID KEDNQQNRMH PFRDDRRSKS IEEREEEYQR VRERIFAHDS VCSQESLFVE NSRLLEDSNI CNETYKKRQL FRGNRDGSGR TSGSRQSSSE NELKWSDHQR AWSSTDSDSS NRNLKPAMTK TASFGGITVL TRGDSTSSTR STGKLSKAGS ESSSSAGSSG SLSRTHPPLQ STPLVSGVAA GSPGCVPYPE NGIGGQVAPS STSYILLPLE AATGIPPGSI LLNPHTGQPF VNPDGTPAIY NPPTSQQPLR SAMVGQSQQQ PPQQQPSPQP QQQVQPPQPQ MAGPLVTQRD DVATQFGQMT LSRQSSGETP EPPSGPVYPS SLMPQPAQQP SYVIASTGQQ LPTGGFSGSG PPISQQVLQP PPSPQGFVQQ PPPAQMPVYY YPSGQYPTST TQQYRPMAPV QYNAQRSQQM PQAAQQAGYQ PVLSGQQGFQ GLIGVQQPPQ SQNVINNQQG TPVQSVMVSY PTMSSYQVPM TQGSQGLPQQ SYQQPIMLPN QAGQGSLPAT GMPVYCNVTP PTPQNNLRLI GPHCPSSTVP VMSASCRTNC ASMSNAGWQV KF
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