Phosphatidylethanolamine N-methyltransferase (PEMT)

About Phosphatidylethanolamine N-methyltransferase

Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein from Homo sapiens identified by UniProt accession Q9UBM1, 199 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.

Target properties

Protein name	Phosphatidylethanolamine N-methyltransferase
UniProt accession	Q9UBM1
Gene	PEMT
Organism	Homo sapiens
Length	199 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (148)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.44
BMI-adjusted waist-hip ratio · score 0.40
BMI-adjusted hip circumference · score 0.39
phosphatidylcholine measurement · score 0.38
waist-hip ratio · score 0.37
high density lipoprotein cholesterol measurement · score 0.32
phosphatidylinositol measurement · score 0.29
apolipoprotein A 1 measurement · score 0.27
appendicular lean mass · score 0.25
lean body mass · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBM1-F1	alphafold	PREDICTED	93.61	—

Amino-acid sequence (199 residues)

MTRLLGYVDP LDPSFVAAVI TITFNPLYWN VVARWEHKTR KLSRAFGSPY LACYSLSVTI LLLNFLRSHC FTQAMLSQPR MESLDTPAAY SLGLALLGLG VVLVLSSFFA LGFAGTFLGD YFGILKEARV TVFPFNILDN PMYWGSTANY LGWAIMHASP TGLLLTVLVA LTYIVALLYE EPFTAEIYRQ KASGSHKRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards