7-dehydrocholesterol reductase (DHCR7)

About 7-dehydrocholesterol reductase

7-dehydrocholesterol reductase (DHCR7) is a protein from Homo sapiens identified by UniProt accession Q9UBM7, 475 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.

Target properties

Protein name	7-dehydrocholesterol reductase
UniProt accession	Q9UBM7
Gene	DHCR7
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (244)

Diseases linked to this target (Open Targets).

Smith-Lemli-Opitz syndrome · score 0.88
vitamin D measurement · score 0.61
genetic disorder · score 0.55
neurodegenerative disease · score 0.48
Cataract · score 0.46
Intellectual disability · score 0.46
disorder of sexual differentiation · score 0.46
2-3 toe syndactyly · score 0.41
Elevated circulating 7-dehydrocholesterol concentration · score 0.41
Small for gestational age · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBM7-F1	alphafold	PREDICTED	91.23	—

Amino-acid sequence (475 residues)

MAAKSQPNIP KAKSLDGVTN DRTASQGQWG RAWEVDWFSL ASVIFLLLFA PFIVYYFIMA CDQYSCALTG PVVDIVTGHA RLSDIWAKTP PITRKAAQLY TLWVTFQVLL YTSLPDFCHK FLPGYVGGIQ EGAVTPAGVV NKYQINGLQA WLLTHLLWFA NAHLLSWFSP TIIFDNWIPL LWCANILGYA VSTFAMVKGY FFPTSARDCK FTGNFFYNYM MGIEFNPRIG KWFDFKLFFN GRPGIVAWTL INLSFAAKQR ELHSHVTNAM VLVNVLQAIY VIDFFWNETW YLKTIDICHD HFGWYLGWGD CVWLPYLYTL QGLYLVYHPV QLSTPHAVGV LLLGLVGYYI FRVANHQKDL FRRTDGRCLI WGRKPKVIEC SYTSADGQRH HSKLLVSGFW GVARHFNYVG DLMGSLAYCL ACGGGHLLPY FYIIYMAILL THRCLRDEHR CASKYGRDWE RYTAAVPYRL LPGIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards