Dickkopf-related protein 3 (DKK3)

About Dickkopf-related protein 3

Dickkopf-related protein 3 (DKK3) is a protein from Homo sapiens identified by UniProt accession Q9UBP4, 350 residues long. MolForge cross-references it against 0 known binders and 409 disease associations.

Target properties

Protein name	Dickkopf-related protein 3
UniProt accession	Q9UBP4
Gene	DKK3
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (409)

Diseases linked to this target (Open Targets).

Dickkopf-related protein 3 measurement · score 0.40
refractive error measurement · score 0.39
body height · score 0.38
cortical surface area measurement · score 0.34
autosomal dominant polycystic liver disease · score 0.34
Isolated polycystic liver disease · score 0.34
brain volume measurement · score 0.31
serum gamma-glutamyl transferase measurement · score 0.31
neuroimaging measurement · score 0.31
brain measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBP4-F1	alphafold	PREDICTED	73.56	—

Amino-acid sequence (350 residues)

MQRLGATLLC LLLAAAVPTA PAPAPTATSA PVKPGPALSY PQEEATLNEM FREVEELMED TQHKLRSAVE EMEAEEAAAK ASSEVNLANL PPSYHNETNT DTKVGNNTIH VHREIHKITN NQTGQMVFSE TVITSVGDEE GRRSHECIID EDCGPSMYCQ FASFQYTCQP CRGQRMLCTR DSECCGDQLC VWGHCTKMAT RGSNGTICDN QRDCQPGLCC AFQRGLLFPV CTPLPVEGEL CHDPASRLLD LITWELEPDG ALDRCPCASG LLCQPHSHSL VYVCKPTFVG SRDQDGEILL PREVPDEYEV GSFMEEVRQE LEDLERSLTE EMALREPAAA AAALLGGEEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards