tRNA (guanine-N(7)-)-methyltransferase (METTL1)

About tRNA (guanine-N(7)-)-methyltransferase

tRNA (guanine-N(7)-)-methyltransferase (METTL1) is a protein from Homo sapiens identified by UniProt accession Q9UBP6, 276 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	tRNA (guanine-N(7)-)-methyltransferase
UniProt accession	Q9UBP6
Gene	METTL1
Organism	Homo sapiens
Length	276 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
Abnormality of neuronal migration · score 0.11
cancer · score 0.10
neoplasm · score 0.10
hepatocellular carcinoma · score 0.10
lung adenocarcinoma · score 0.10
breast cancer · score 0.10
acute myeloid leukemia · score 0.08
esophageal squamous cell carcinoma · score 0.08
calf circumference measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBP6-F1	alphafold	PREDICTED	88.04	—

Amino-acid sequence (276 residues)

MAAETRNVAG AEAPPPQKRY YRQRAHSNPM ADHTLRYPVK PEEMDWSELY PEFFAPLTQN QSHDDPKDKK EKRAQAQVEF ADIGCGYGGL LVELSPLFPD TLILGLEIRV KVSDYVQDRI RALRAAPAGG FQNIACLRSN AMKHLPNFFY KGQLTKMFFL FPDPHFKRTK HKWRIISPTL LAEYAYVLRV GGLVYTITDV LELHDWMCTH FEEHPLFERV PLEDLSEDPV VGHLGTSTEE GKKVLRNGGK NFPAIFRRIQ DPVLQAVTSQ TSLPGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards