Glyoxylate reductase/hydroxypyruvate reductase (GRHPR)

About Glyoxylate reductase/hydroxypyruvate reductase

Glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a protein from Homo sapiens identified by UniProt accession Q9UBQ7, 328 residues long. MolForge cross-references it against 0 known binders and 206 disease associations.

Target properties

Protein name	Glyoxylate reductase/hydroxypyruvate reductase
UniProt accession	Q9UBQ7
Gene	GRHPR
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (206)

Diseases linked to this target (Open Targets).

primary hyperoxaluria type 2 · score 0.78
primary hyperoxaluria · score 0.58
nephrolithiasis · score 0.38
nephrocalcinosis · score 0.33
Nephrocalcinosis · score 0.19
primary hyperoxaluria type 3 · score 0.09
nephrolithiasis, calcium oxalate, 2, with or without nephrocalcinosis · score 0.07
nephrotic syndrome · score 0.07
daytime rest measurement · score 0.07
familial idiopathic steroid-resistant nephrotic syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBQ7-F1	alphafold	PREDICTED	96.89	—

Amino-acid sequence (328 residues)

MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards