Beta-ureidopropionase (UPB1)

About Beta-ureidopropionase

Beta-ureidopropionase (UPB1) is a protein from Homo sapiens identified by UniProt accession Q9UBR1, 384 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Beta-ureidopropionase
UniProt accession	Q9UBR1
Gene	UPB1
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

beta-ureidopropionase deficiency · score 0.80
serum gamma-glutamyl transferase measurement · score 0.54
genetic disorder · score 0.49
serum metabolite measurement · score 0.29
acne · score 0.28
tea consumption measurement · score 0.26
cutaneous melanoma · score 0.22
coffee consumption measurement · score 0.18
Abnormal urine sodium concentration · score 0.15
leukocyte count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBR1-F1	alphafold	PREDICTED	97.00	—

Amino-acid sequence (384 residues)

MAGAEWKSLE ECLEKHLPLP DLQEVKRVLY GKELRKLDLP REAFEAASRE DFELQGYAFE AAEEQLRRPR IVHVGLVQNR IPLPANAPVA EQVSALHRRI KAIVEVAAMC GVNIICFQEA WTMPFAFCTR EKLPWTEFAE SAEDGPTTRF CQKLAKNHDM VVVSPILERD SEHGDVLWNT AVVISNSGAV LGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL NWLMYSINGA EIIFNPSATI GALSESLWPI EARNAAIANH CFTCAINRVG TEHFPNEFTS GDGKKAHQDF GYFYGSSYVA APDSSRTPGL SRSRDGLLVA KLDLNLCQQV NDVWNFKMTG RYEMYARELA EAVKSNYSPT IVKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards