LIM/homeobox protein Lhx3 (LHX3)

About LIM/homeobox protein Lhx3

LIM/homeobox protein Lhx3 (LHX3) is a protein from Homo sapiens identified by UniProt accession Q9UBR4, 397 residues long. MolForge cross-references it against 0 known binders and 226 disease associations.

Target properties

Protein name	LIM/homeobox protein Lhx3
UniProt accession	Q9UBR4
Gene	LHX3
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (226)

Diseases linked to this target (Open Targets).

non-acquired combined pituitary hormone deficiency with spine abnormalities · score 0.77
neurodegenerative disease · score 0.49
sex hormone-binding globulin measurement · score 0.39
hypothyroidism due to deficient transcription factors involved in pituitary development or function · score 0.38
erythrocyte count · score 0.38
sensorineural hearing loss · score 0.37
Sensorineural hearing impairment · score 0.37
thyroxine measurement · score 0.36
hormone measurement · score 0.35
red blood cell density measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBR4-F1	alphafold	PREDICTED	67.18	—

Amino-acid sequence (397 residues)

MLLETGLERD RARPGAAAVC TLGGTREIPL CAGCDQHILD RFILKALDRH WHSKCLKCSD CHTPLAERCF SRGESVYCKD DFFKRFGTKC AACQLGIPPT QVVRRAQDFV YHLHCFACVV CKRQLATGDE FYLMEDSRLV CKADYETAKQ REAEATAKRP RTTITAKQLE TLKSAYNTSP KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RQRWGQYFRN MKRSRGGSKS DKDSVQEGQD SDAEVSFPDE PSLAEMGPAN GLYGSLGEPT QALGRPSGAL GNFSLEHGGL AGPEQYRELR PGSPYGVPPS PAAPQSLPGP QPLLSSLVYP DTSLGLVPSG APGGPPPMRV LAGNGPSSDL STGSSGGYPD FPASPASWLD EVDHAQF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards