About Dickkopf-related protein 4
Dickkopf-related protein 4 (DKK4) is a protein
from Homo sapiens identified by UniProt accession
Q9UBT3, 224 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Dickkopf-related protein 4 |
|---|
| UniProt accession | Q9UBT3 |
|---|
| Gene | DKK4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 224 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- hepatocellular carcinoma · score 0.17
- neoplasm · score 0.10
- tissue plasminogen activator measurement · score 0.09
- cancer · score 0.08
- gastrointestinal stromal tumor · score 0.08
- colorectal carcinoma · score 0.07
- hemoglobin measurement · score 0.06
- systolic blood pressure · score 0.05
- pulse pressure measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBT3-F1 | alphafold | PREDICTED | 73.71 | — |
Amino-acid sequence (224 residues)
MVAAVLLGLS WLCSPLGALV LDFNNIRSSA DLHGARKGSQ CLSDTDCNTR KFCLQPRDEK PFCATCRGLR RRCQRDAMCC PGTLCVNDVC TTMEDATPIL ERQLDEQDGT HAEGTTGHPV QENQPKRKPS IKKSQGRKGQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL
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