About Dickkopf-related protein 2
Dickkopf-related protein 2 (DKK2) is a protein
from Homo sapiens identified by UniProt accession
Q9UBU2, 259 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Target properties
| Protein name | Dickkopf-related protein 2 |
|---|
| UniProt accession | Q9UBU2 |
|---|
| Gene | DKK2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 259 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (204)
Diseases linked to this target (Open Targets).
- hair shape measurement · score 0.46
- balding measurement · score 0.45
- blood protein measurement · score 0.38
- PHF-tau measurement · score 0.33
- brain measurement · score 0.32
- cortical surface area measurement · score 0.32
- androgenetic alopecia · score 0.29
- alopecia · score 0.25
- telomere length · score 0.22
- lysophosphatidylcholine measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBU2-F1 | alphafold | PREDICTED | 70.45 | — |
Amino-acid sequence (259 residues)
MAALMRSKDS SCCLLLLAAV LMVESSQIGS SRAKLNSIKS SLGGETPGQA ANRSAGMYQG LAFGGSKKGK NLGQAYPCSS DKECEVGRYC HSPHQGSSAC MVCRRKKKRC HRDGMCCPST RCNNGICIPV TESILTPHIP ALDGTRHRDR NHGHYSNHDL GWQNLGRPHT KMSHIKGHEG DPCLRSSDCI EGFCCARHFW TKICKPVLHQ GEVCTKQRKK GSHGLEIFQR CDCAKGLSCK VWKDATYSSK ARLHVCQKI
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