Appetite-regulating hormone (GHRL)

About Appetite-regulating hormone

Appetite-regulating hormone (GHRL) is a protein from Homo sapiens identified by UniProt accession Q9UBU3, 117 residues long. MolForge cross-references it against 0 known binders and 815 disease associations.

Target properties

Protein name	Appetite-regulating hormone
UniProt accession	Q9UBU3
Gene	GHRL
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (815)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.26
breast adenocarcinoma · score 0.25
obesity · score 0.24
self reported educational attainment · score 0.21
head and neck squamous cell carcinoma · score 0.17
type 2 diabetes mellitus · score 0.13
neoplasm · score 0.11
insulin resistance · score 0.11
Sepsis · score 0.11
obstructive sleep apnea · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBU3-F1	alphafold	PREDICTED	63.99	—

Amino-acid sequence (117 residues)

MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRVQQRKE SKKPPAKLQP RALAGWLRPE DGGQAEGAED ELEVRFNAPF DVGIKLSGVQ YQQHSQALGK FLQDILWEEA KEAPADK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards