About Nuclear RNA export factor 1
Nuclear RNA export factor 1 (NXF1) is a protein
from Homo sapiens identified by UniProt accession
Q9UBU9, 619 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Nuclear RNA export factor 1 |
|---|
| UniProt accession | Q9UBU9 |
|---|
| Gene | NXF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 619 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- chronic lymphocytic leukemia · score 0.48
- neurodegenerative disease · score 0.19
- mean platelet volume · score 0.14
- infection · score 0.05
- infect · score 0.05
- mean reticulocyte volume · score 0.03
- BMI-adjusted waist circumference · score 0.03
- BMI-adjusted waist-hip ratio · score 0.03
- waist-hip ratio · score 0.02
- reticulocyte measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBU9-F1 | alphafold | PREDICTED | 79.46 | — |
Amino-acid sequence (619 residues)
MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS RLEEDDGDVA MSDAQDGPRV RYNPYTTRPN RRGDTWHDRD RIHVTVRRDR APPERGGAGT SQDGTSKNWF KITIPYGRKY DKAWLLSMIQ SKCSVPFTPI EFHYENTRAQ FFVEDASTAS ALKAVNYKIL DRENRRISII INSSAPPHTI LNELKPEQVE QLKLIMSKRY DGSQQALDLK GLRSDPDLVA QNIDVVLNRR SCMAATLRII EENIPELLSL NLSNNRLYRL DDMSSIVQKA PNLKILNLSG NELKSERELD KIKGLKLEEL WLDGNSLCDT FRDQSTYISA IRERFPKLLR LDGHELPPPI AFDVEAPTTL PPCKGSYFGT ENLKSLVLHF LQQYYAIYDS GDRQGLLDAY HDGACCSLSI PFIPQNPARS SLAEYFKDSR NVKKLKDPTL RFRLLKHTRL NVVAFLNELP KTQHDVNSFV VDISAQTSTL LCFSVNGVFK EVDGKSRDSL RAFTRTFIAV PASNSGLCIV NDELFVRNAS SEEIQRAFAM PAPTPSSSPV PTLSPEQQEM LQAFSTQSGM NLEWSQKCLQ DNNWDYTRSA QAFTHLKAKG EIPEVAFMK
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